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Does CBD Stop Pain? How CBD Oil Affects Chronic Pain and Inflammation by Thomas DeLauer


I promised a six month series talking about
CBD. I’m going to do one video a month over the
course of six months talking about CBD and how it affects the body and endocannabinoids
and our natural production of them. This is mainly just to combat a lot of the
nonsense that’s out there. All right. Today, I want to talk about pain and inflammation,
and how CBD affects it, but also how our natural endocannabinoids affect pain, and how the
modulation of inflammation is really just a natural process that all has to do with
cyclooxygenase enzymes and also very specific things called endocannabinoids. All right. Let’s talk first about what inflammation really
is. I’m going to make this quick. All right. Inflammation is simply a response to any kind
of trauma or any kind of immune event in your body, where your body needs an immune response. Okay, we have two different kinds, acute and
chronic. Acute is the kind that you probably know about. When you bump your elbow, when you get a scratch
or a cut, and it gets swollen. It gets swollen and red, that’s simple inflammation. That’s simple cytokine activity triggering
immune cells to fight a given trauma. Then, we have chronic inflammation. It’s the inflammation that’s occurring in
our body all the time, really. It’s constantly happening. Sometimes, it’s worse than other times. This has to do with the fact that our cells
become actually sick and we trigger and immune response, and then it cascades into this vicious
circle, where the immune system responds even more, and more, and more, yielding to chronic
inflammation. Now, normally, when we think of fighting inflammation,
we think of an antiinflammatory. When we talk about antiinflammatory processes
in the body, we think about something known as a nonsteroidal antiinflammatory, aspirin,
ibuprofen, things like that. Yes, those do combat inflammation. Here’s how they actually work. They act upon something known as the cyclooxygenase
enzymes, COX1 and COX2. Cyclooxygenase enzymes are a way to actually
slow down inflammation, definitely, by inhibiting them. The problem is, as you probably already know,
nonsteroidal antiinflammatories are hard on the gut. The reason they’re hard on the gut is because
they stop the production of both COX1 and COX2. One of those cyclooxygenase enzymes we need
to protect our gut. You see, we actually need a little bit of
inflammation in our gut. Anyway, I digress. I want to talk more about how CBD directly
affects inflammatory responses within the body. We have these things in our body called endocannabinoids. They’re endogenous cannabinoids. A lot of times, when we think of cannabinoids,
we think of only something that’s coming from cannabis, something that’s illegal, or something
that really is an exogenous thing coming in. The reality is, we have endogenous cannabinoids. They’re called endocannabinoids and they have
an antiinflammatory effect on the the body. They are a very natural thing. They’re a natural byproduct of fatty acid
metabolism, believe it or not. These endocannabinoids are naturally occurring
members of what are called the eicosanoid families. If you watched some of my other videos, you
know that I talk about eicosapentaenoic acid, also known as EPA. If you’ve ever bought a fish oil pill or any
kind of omega 3, you’ve seen eicosapentaenoic acid, or EPA, on the label, an antiinflammatory
fat that modulates inflammation and does a multitude of other things within the body. Well, these endocannabinoids are a naturally
occurring member of that super family. Within that family, we have a lot of different
things that modulate inflammation. In this particular case, endocannabinoids
are derived from long chain fatty acids. They are a byproduct of the breakdown of long
chain fatty acids, meaning it’s a very natural process to have cannabinoids in our systems. What ends up happening is they’re produced
by fat. Then, when they’re actually needed, when they’re
actually solicited to be used for something, they’re released by the neurons. We have these fats that are broken down, and
we end up with these overall cannabinoids, but they don’t get released until the neurons
say so. The neurons actually see some inflammation
or they see something, they’re going to release more od these to modulate it. It’s this natural progression of fats communicating
with neurons to ultimately release these endocannabinoids. Let’s take it a little bit further to understand
how this works. Now, that means we have to understand cytokines. You see, cytokines are signaling proteins
that ultimately recruit inflammation to happen. Cytokines will trigger specific immune cells
to release inflammation or actually even reduce inflammation, when given the right circumstances. Cytokine activity is not always bad. We do need some cytokine activity. If we got rid of all the cytokines, we wouldn’t
ever have inflammation or it wouldn’t ever be able to be modulated up or down, leaving
us in a really sticky situation. When we get down to CBD, CBD actually modulates
the cytokine production. It works on cytokine production with very
specific cells though. Since we don’t want to get rid of all the
cytokine activity, we do want to get rid of it with specific things. So, very specific immune cells that overactive
that are causing inflammation in our joints all the time or causing inflammation in our
brain, they can be become reduced with the instance of CBD being in the equation, simply
because now we have all the stimulation of these natural endocannabinoids to reduce that
inflammation. There’s one specific area of the body that
reduces cytokine activity that’s exceptionally important, and that’s when it comes down to
T helper cells. If you ever heard of T cells before, then
you know that there are two kinds. There are helper cells and there are killer
cells. The helper cells travel around the body and
they slap a label on anything that is potentially bad. That label allows the killer T cells to come
by later and designate that to be killed. Basically, has a label, and now the killer
T cell goes ahead and it kills it, so they’re working in tandem, a two part equation here. What CBD does is it limits the cytokine activity
of these helper T cells, meaning they are not as activated in a bad way. If you have overactive T cells, T helper cells,
they’re going to run around your body, running rampant, slapping a label on everything, triggering
inflammation and triggering killer T cells to come around and start an attack on things
that don’t need to be attacked. You can see how this can lead to a massive
amount of chronic inflammation leading to joint pain, brain fog, digestive discomfort,
all kinds of different things. To help this get in really, really, clear,
I’m going to break down one specific kind of endocannabinoid. Now, there are a multitude of them, but this
particular one is very common and it’s one of the most well researched. It’s called anandamide. Anandamide is a naturally occurring cannabinoid. It’s a endocannabinoid that, by using CBD
oil, your body naturally creates more of. Remember, I’ve talked about this in other
videos, but CBD does not react with the CBD1 and CBD2 receptors. Okay? It does not do that like traditional cannabis
would. It’s not a recreational drug. What it does is it allows your body to naturally
create more of the endocannabinoids that are good. Endocannabinoids, like Anandamide. Let’s talk about how that actually works. Not only does CBD naturally increase anandamide
as is, it also reduces the cytokine activity that would normally inhibit it. We’re talking about the cytokine activity
associated with Tumor necrosis factor 1 alpha, TNF1-a, very, very, common in the world of
inflammation. By reducing TNF1-a, we reduce the body’s ability
to fight off production of anandamide. By reducing the activity of Tumor necrosis
factor 1 alpha, we also reduce the activity of aminohydrolase. This is a byproduct of fatty acid metabolism
that can actually have a negative effect on overall endocannabinoid activity. Basically, all this means is, by reducing
the cytokine activity of these two things, we are allowing endocannabinoids to do their
jobs better, and we are allowing anandamide to come into fruition, and we create more
of it. If you don’t know anandamide, it is very much
so responsible for creating bliss within the body, reducing inflammation in the joints,
but also reducing inflammation in the brain. It truly is known as the bliss product of
the body, because that’s the sensation that best describes what anandamide does. In knowing that, we have to wonder, well how
exactly does it do that? Well, it’s because it holds the key to be
able to turn off nuclear factor kappa B, or at least greatly reduce it. Nuclear factor kappa B is one of the most
widely researched inflammatory substances within the body. It is basically the master control switch,
when it comes down to inflammation. If we can reduce nuclear factor kappa B, we
can reduce the actual DNA result of inflammation within our body. You see, if nuclear factor kappa B is always
elevated, it can change our DNA to be used to having high amounts of inflammation. So really, anandamide is one of the keys to
actually getting rid of this problem where our bodies are getting so accustomed to inflammation
that we’re just adapting to become these inflamed creatures. It truly is allowing our body to turn off
that master switch when it comes down to inflammation. Mind you, it is doing this all without ever
activating CBD1 or CBD2 receptors within the body. I will say that again. It does not affect CBD1 or CBD2 receptors
in the body. A lot of marketing collateral out there will
tell you that CBD oil does directly affect one of the CBD receptors. Not that case at all. All CBD oils do the same thing. They naturally increase the production of
our preexisting endocannabinoids. Very, very, critical. I know this was very in depth. I was talking about cytokines. I was talking about all kinds of inflammatory
markers in the body, but it’s important that you know that, at the end of the day, it is
a solid way to modulate and reduce inflammation in the body without acting about the cyclooxygenase
enzymes that are going to destroy your gut and lead to a lot of other damaging things
in your life. As always, if you like these CBD videos, let
me know down in the comment sections below. I’m going to make sure I keep them coming
to you for the next couple of months, so that you have a solid understanding of what truly
is going on in the products, but also what’s going on in your body, not just in a product
that you take. I’ll see you in the next video.

100 thoughts on “Does CBD Stop Pain? How CBD Oil Affects Chronic Pain and Inflammation by Thomas DeLauer

  1. Can one expect the same benefits when using tinctures? I live in NV, and cannibis products are legal here. CBD can be purchases easily, but most CBD products are mixed with varying levels of THC. You can get straight CBD, but it's really expensive. Does the THC mixed CBD reduce the health benefits?

  2. Question…..If CBD oil works so great for just about everything. Then why does eating or smoking high quality weed just get me really high and does little to nothing for my pain? I can also pick fully mature wild hemp buds in the fall loaded with mature seeds and eat a fresh 4 ounce salad of hemp seed/buds and it does nothing for my pain. So I don't understand how this CBD oil can work so great for everybody. If weed and hemp does nothing for pain, is CBD oil the concentrated CBD extract of say, 15 mature plants into 1 little vial?

  3. I’m a medical professional and am impressed with not only your pronunciation of these terms, but also your speed. Seriously, good job.

  4. If you could just speak in layman's terms it would be deeply appreciated. Information you are giving us is above everyone's head. We need positive information we're not stupid so please stick to the subject and answer the question how to use CBD does CBD actually work how long should you use it.? Thank you sincerely Arnold Bourbon Amaral

  5. Best pain relief for chronic pain, is called the entarauge affect. I use cbd first wait 30 mins, take 2 riffs off bong and get better relief then cbd by itself. Just for me, maybe not for you. But I've had chronic pain from 5 failed back surgeries, been on all the pain pills. FOR MEE, it works best if used in conjunction with some good India. As I said this is what works best for ME.

  6. I have a question regarding CBD Isolate and cbd full spectrum. I can’t take the full spectrum due to random drug tests and my jobs zero tolerance policy. Do the isolate tinctures and vape products have the same effect or is full spectrum a must?

  7. I have fibromyalgia it's . central nervous system pain pathway neurological pain. Do you recommend any sort of CBD oil or marijuana to help with the pain other than using opioids. I'll keep in mind there is no inflammation in fibromyalgia that's some big misconception everyone's had it's up maybe 10 or 15 different feelings of pain so this is all stemming from nervous system in the pain Pathway to the brain I tried a cannabinoid in a tablet and a capsule but it didn't have any effect whatsoever so I'm just wondering is it wasting my time to go and purchase and get a prescription for it or should I just stay with the opioids. As you know fibromyalgia has been around for a long long time back when they called it rheumatism. Is there such potent medication for sleep insomnia to eliminate seditives and benzo medication. Okay thank you very much for any help you can offer me! You sound intelligent on the topic.

  8. If there's anyone on this platform that doesn't have any sort of acute or chronic pain that is intense and severe you just jump right off the topic as you're trying to learn about something that's different but if you're trying to preach about chronic pain in certain conditions like fibromyalgia you can't make people feel like it's something that isn't as serious as it is.

  9. Whatever you do, make sure you are buying pure CBD. NO GMO’S, NO PESTICIDE, NO ADDITIVES OR FILLERS. Make sure it's ORGANIC & 3RD PARTY TESTED. If you need help finding this, just ask.

  10. I have tried this in a BALM form on my Hands too cut down. Arthritic Pain to no avail. would it work better if in OIL form??

  11. my mom can't use her left arm and hand from stroke can cbd make new cells in the brain then she can use it?

  12. What r ur thoughts about Irwin Naturals CBD line? I only ask due to your clear expertise but also because they are so far the one product that’s affordable for me. Thank you!!! 💘👍

  13. So does it matter if it's full spectrum CBD or pure? I've read before that only CBD-A is able to reduce pain. Problem is there is less CBD-A in a full spectrum product than THC, which by law has to be less than .3%. I take 80mg full spectrum once or twice a day for degenerative disk in my Cspine. It helps, but doesn't eliminate.

  14. It’s CB1 and CB2…not CBD1 and CBD2. Can’t stand hearing you say that. It makes you sound uneducated. It’s also anandamide not andandamide…good presentation but get your words right

  15. Back in February I had a hard time closing my fists on both hands. I have never had that problem.
    I heard on the local radio station a little store that opened about a mile from the house. The commercial said they were selling lotion that had CBD oil in it. I figure what the heck. I could go to the doctor and get some pills and have a dozen side effects or try this.
    I went down to the store on Saturday. I purchased about a 4oz bottle of this cream called Bud’s Deluxe. They have it in 250mg, 500mg, 1000mg and 1500mg strength. I got the 500mg and went home. That day I put it on the back of my hands on my knuckles. On Sunday I applied and 2nd coat.
    Monday morning when I woke up I could make a tight fist and snap my fingers! Wow this stuff works. I told some elderly ladies about this and one went down to the store, https://the-smoking-pot-coffee-shop.business.site/
    Their address is 8510 Long Point Rd. Houston, Tx I picked up a container (pump top applicator).
    The next week I ask if it worked. She said her shoulder pain went away. She even put it on her neck for pain and that went away.

    Who would ever think that stuff works. This was right under our nose for decades. You want to keep it out of the food and drug business, as they will say it no good and try to control it.

    Maxwell House Coffee plant here in Houston closed up about a year ago.
    Another company is coming in and are processing the hemp plant to make the liquid drops and cream. They are going to put 500 people to work.

    Farmers in Texas are gearing up to raise the hemp under strict quality control.
    I can say I can snap my fingers like I used to when I was 32 years old !

    Thanks for reading…..

  16. Thanks for ur information bcos i m introduce CBD oil (here i call herb C oil) and its work for imflammation and cancer hidh blood, gout and all cronik sickness.. Its work really so now i m introducing it to many peoples bcos im so pity to see peoples sick and why me and daughters.. Do reserch what product is the best. And its CBD oil.. But we get cure from our local suppilment.. Bcos we its not legal here in my country bcos just get it for sick peoples..

  17. I'm new to all this , but very interested , would what you explained in this video happen if you apply with a cream on the sore area or ingested orally ? very impressed with your video, Thank you

  18. Absorption is very important when taking any nutrient. Like most people who are gluten intolerant, the effect may be very limited.

  19. This video is very informative so much so I think I will do a set of chin-ups in honor.   And I will add that if a person consumes high sources of nutrition the benefits that come from hemp oil or CBD will be magnified. Example there is something in red cherries that improve upon the way electrical impulses flow throughout the body.   Keep in mind nothing happens within the body without a electrical impulse.    Red beets improve upon the circulation throughout the entire body. Wheatgrass allows the blood cells to maintain oxygen more efficiently.  Bone marrow strengthens the teeth eyes hair nails bones tendons ligaments muscles over all skeleton structure.  At the same time it detoxifies the liver which is the primary organ that helps the body cleanse itself from any harmful toxins.   9 g of protein per tablespoon,  this   particular type of protein is easy for the body to break down and absorb digest and put to use so it is female and child friendly. Think about this for most of a person's life there skeleton structure is breaking down deteriorating it does heal itself to a certain degree.   However nowhere near to the effect that bone marrow will.    Which brings me to my next point for when a person skeleton structure is constantly breaking down deteriorating that takes a lot of energy for the body to manage deal with just to stabilize.  Now with the bone marrow powder you will be rejuvenating replenishing the overall skeleton structure freeing up all that excess energy that went into stabilizing to be used for other functionalities within the body such as adjust adapt respond recover.    This method will improve upon the most extreme situations even if the are polar opposites example those in special forces training or those who are in the critical care unit going to be facing many years of rehabilitation.  Or even the most common basic average normal problems that stem from those just being soft lazy out of shape overfed undernourished overworked and underpaid with dirty low-paying jobs.  Thank you for sharing your time here on YouTube.

  20. Hey Thomas, Is CBD oil better than water soluble CBD? I've seen way too many arguments about this and can't seem to really find the answer. I'd greatly appreciate your assistance

  21. No CBD oil I've tried helped one tiny bit. I have chronic migraines and neck pain. And now my pain is spreading so probably fibromyalgia.

  22. It really works oh thank god… Just down anything for inflammation( tart cherry, ginger, pineapple) and some CBD, it calms everything down in a matter of minutes

  23. Short answer, yes. . CBD does help with many things. . Such as inflammation, seizures in many people, stress and insomnia with many people as well.

  24. please slow down your lecture. I am a 63-year-old man with chronic pain syndrome and he retired physiologist who quite frankly had great difficulty following you. Like others I need the content and will follow you as you appear to be a great educator that said please appreciate the fact that there are a multitude of different learning Styles in your audience. Thanks much

  25. Thomas, I am so grateful for your thorough video because I am new to using CBD oil in fact I have just received my 1st bottle that I have paid a considerable amount of money for and yet I have no idea how to use it to help with my over all inflammation for rheumatoid arthritis and you seem like the person with the knowledge to help me. Is it possible to set up a consultation with you or can you direct me to information on how to internally or topically use my hemp oil?

  26. I'm glad this video exists! Definitely tells everyone that's CBD is totally natural and a brilliant anti inflammatory tool for overall body function.

    Try tell us that science is a lie government! 🤜

  27. I have a CBD business and I never tell anyone to start with such a high dose. He doesn't say what the CBD mg strength is, and of course he was over tired and falling asleep because he was taking too much at one time and in one day! This guy does not appear to be very serious about giving CBD a chance to prove itself, and between him and the doctor he consulted with, the impression given is that CBD just MIGHT help with certain conditions. This makes me sad and angry, because Hemp sourced CBD and marijuana too, were used for medicinal purposes for hundreds, if not thousands of years, all across the globe and the only reason that changed was due to lies and negative propaganda put out by greedy corporations and politicians. I urge everyone to do their research and choose natural medicine that literally has no known side effects, unless you take too much at one time. Blessings to everyone for a healthy, happy and pain free life 🙂

  28. Don't buy the hype. I'm still testing it and have found no redeeming value in CBD oil. It may possibly help a person get some sleep… still testing, though.

  29. THOMAS you really need to research Zilis. It’s the country’s number one selling full spectrum water soluble hemp oil by both revenue and SCU. Check out Zilis.com/chad and keely. Check out Doctor DeSilva and Doctor Matt Andry. Both are experts in this area.

  30. hey so i have a question. i have had plantar fasciitis in both feet/heels…as of late my left ankle has been very inflammated . could and would you be able to recommend me a great CBD oil to take because ive tried everything ( non steroid inflammation pills, cortisone shots) and nothing has helped!!…please get back to me , thank you.

  31. I work 60 hours a week and all that time is on my feet. Four days are 12 hour days. Before CBD my feet at the end of the day were inflamed.

  32. Each time I take pure CBD even a drop of lower potency CBD 200 with less than 0.3% THC I get anxious and also feel high? Does anyone get this too? It’s the opposite effect of what I’m told it should do or want it to do…

  33. Hemp CBD is federally legal. Cannabis CBD is not legal. It’s two separate plants that look similar, it’s tricky. The Amish farm sells it near my ranch…. I admit I was starting to get curious and not sure what the heck they were growing!

  34. Does anybody have any suggestions on which specific brands of CBD oils, I keep hearing how great it is, but haven’t found much on quality brands or manufacturers.
    Thanks for any help y’all can provide.

  35. I have brain cancer. Metastatic melanoma. 3 weeks post brain surgery…problematic chronic pain. Back n forth to hospital with PAIN…pain management etc. A lot of brain swelling and severe headaches. I tried CBD and my pain has serioisly decreased💙💚💜 Amazing💙

  36. Wow! That is indepth into but very informative you nearly lost me with all that technical info but I did find it interesting and informative as I've just started taking CBC oil due to health condition so good to know there is no bad effects only good I hope it works out for me.

  37. Your videos are very helpful I like that it's easy going straight to the point and I feel like I'm missing you too my friend give me some quality information to better my life. I really appreciate you doing this and hope that your Channel does very well.We have a website if you're interested in promoting your organization hempyshub.com

  38. I got information from 2 bad knee surgeries CBD creams in my own opinion the cream is better than the oil I get 500 mg my knee is very stiffness injury on job 2001 The 500 mg cream is does takes the stillness aways

  39. I am going to try CBD oil, but I do have a concern. After researching about CBD I have come across some articles stating that CBD can cause liver damage. The FDA approved medication which contains CBD is called Epidolex. Apparently it has a warning about liver damage. Do I need to be concerned when consuming store bought CBD oil products? Thanks.

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